Achtung: Bitte beachten Sie unbedingt die Nutzungsbedingungen. Trotz sorgfältiger Prüfung wird keinerlei Haftung für die dargestellten Inhalte übernommen. Alle Inhalte richten sich ausschließlich an ein ärztliches Fachpublikum.

Keine Kategorien vergeben

Knochen-, Gelenks- und Protheseninfektionen

Kapitelinformationen
Stand: Juni 2021
Kapitelleitung: Norma Jung
Autor:innen: Rika Draenert, Norma Jung, Anna Philine Karl, Thomas Köhler, Katrin Kösters, Franka Lestin-Bernstein
Reviewer:innen: Sören Becker
Beteiligte Fachgesellschaften: dgi-logo.png
Feedback: Mitwirken



Inhaltsverzeichnis








Unterkapitel

Unterkapitel bearbeiten

Diabetischer Fuß
Hämatogene Osteomyelitis
Infektionen nach offenen Frakturen
Osteomyelitis bei Kindern
Periprothetische Infektionen
Septische Arthritis
Spondylodiszitis


Quellen

A. Podbielski, M. Abele-Horn, K. Becker, E. Kniehl, et al. (Hrsg.): MiQ: Qualitätsstandards in der mikrobiologischen-infektiologischen Diagnostik. Elsevier 10/2020.

Abele-Horn M. Spondylodiszitis/Osteomyelitis der Wirbelkörper IN: Antimikrobielle Therapie: Entscheidungshilfen zur Behandlung und Prophylaxe von Infektionskrankheiten. Aktiv Druck & Verlag GmbH. 16. September 2020

Aggarwal VK, Bakhshi H, Unter Ecker N et al: Organism profile in periprothetic joint infection: pathogens differ at two arthroplasty infection referral centers in Europe and in the United States. J Knee Surg 2014: 27:399-406.

Akgün D, et al. Infektionen der Wirbelsäule In: Orthopädie und Unfallchirurgie up2date 2020; 15: 143–157.

American Academy of Orthopaedic Surgeons. Diagnosis and Prevention of Periprosthetic Joint Infections Clinical Practice Guideline. https://www.aaos.org/pjiguideline. PublishedMarch 11, 2019.

Arbeitskreis Krankenhaus- und Praxishygiene der AWMF. Empfehlungen zur Hygiene in Klinik und Praxis. Intraartikuläre Punktionen und Injektionen: Hygienemaßnahmen. AWMF Leitlinien Register 029/006. Stand 08/2015.

AWMF - S1-Leitlinie 012/010: Bakterielle Gelenkinfektionen aktueller Stand: 06/2014

Bariteau JT, Waryasz GR, McDonnell M, Fischer SA, Hayda RA, Born CT. Fungal osteomyelitis and septic arthritis. J Am Acad Orthop Surg. 2014;22(6):390-401. doi:10.5435/JAAOS-22-06-390

Behmanesh B, Gessler F, Schnoes K et al. Infective endocarditis in patients with pyogenic spondylodiscitis: implications for diagnosis and therapy.Neurosurg Focus 2019; 46: E2. DOI 10.3171/2018.10.FOCUS18587

Berbari EF, Kanj SS, Kowalski TJ et al. 2015 Infectious Diseases Society of America (IDSA) clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults. Clin Infect Dis 2015; 61: e26-46.

Bettini N, Girardo M, Dema E, et al. Evaluation of conservative treatment of non specific spondylodiscitis. Eur Spine J 2009; 18 Suppl 1: 143-50.

Boucher HW. Partial Oral Therapy for Osteomyelitis and Endocarditis - Is It Time? N Engl J Med 2019, 380(5):487-489.

Brunkhorst FM, Weigand M, Pletz M et al: S3 Leitlinie Sepsis - Prävention, Diagnose, Therapie und Nachsorge. AWMF Register 079/001. Stand 2018.

Bundesamt S: Diagnosedaten der Krankenhäuser ab 2000 (Eckdaten der vollstationären Patienten und Patientinnen). Gliederungsmerkmale: Jahre, Behandlungs-/Wohnort, ICD10. In., 19.04.2017 edn: Statistisches Bundesamt; 2017

C. Lehmann B. R. Ruf N. Jung (Hrsg.) Infektiologie. Antworten prägnant und praxisnah - PDF Kostenfreier Download. Accessed January 8, 2022. https://docplayer.org/187325549-C-lehmann-b-r-ruf-n-jung-hrsg-infektiologie-antworten-praegnant-und-praxisnah.html

Cho NH, Shaw JE, Karuranga S, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271-281. doi:10.1016/j.diabres.2018.02.023Cornely OA, Bassetti M, Calandra T, Garbino J, Kullberg BJ, Lortholary O, Meersseman W, Akova M, Arendrup MC, Arikan-Akdagli S, Bille J, Castagnola E, Cuenca-Estrella M, Donnelly JP, Groll AH, Herbrecht R, Hope WW, Jensen HE, Lass-Flörl C, Petrikkos G, Richardson MD, Roilides E, Verweij PE, Viscoli C, Ullmann AJ; ESCMID Fungal Infection Study Group. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. Clin Microbiol Infect. 2012 Dec;18 Suppl 7:19-37. doi: 10.1111/1469-0691.12039. PMID: 23137135.

Corvec S, Loiez C, Portillo ME, Rottmann M, Trampuz A. Bone and joint infections. IN: European Manual of Clinical Microbiology 2012. 1st edition

Cottle L, Riordan T. Infectious spondylodiscitis. J Infect. 2008 Jun;56(6):401-12.

Courjon J, Lemaignen A, Ghout I, Therby A, Belmatoug N, Dinh A, Gras G, Bernard L, group DTSs. Pyogenic vertebral osteomyelitis of the elderly: Characteristics and outcomes. PloS one 2017, 12(12):e0188470

Chenot JF, Greitemann B, Kladny B, Petzke F, Pfingsten M, Schorr SG. Non-Specific Low Back Pain. Dtsch Arztebl Int. 2017 Dec 25;114(51-52):883-890.

David K. Hong, Kathleen Gutierrez. “Osteomyelitis”. In Long, Sarah S. MD; Pickering, Larry K. MD; Prober. Principles and practice of pediatric infectious diseases, 5th edition, 2018.

Darley ESR, MacGowan AP. Antibiotic treatment of gram-positive bone and joint infections. J Antimicrob Chemother. 2004;53(6):928-935. doi:10.1093/jac/dkh191

Deutsche Gesellschaft Für Unfallchirurgie. S2k-Leitlinie Akute und chronische exogene Osteomyelitis langer Röhrenknochen des Erwachsenen. AWMF online (2012), https://www.awmf.org/uploads/tx_szleitlinien/012-033l_S2k_Osteomyelitis_2018-01_1.pdf, abgerufen am 02.08.2021

DGPI Handbuch “Infektionen bei Kindern und Jugendlichen”, 7. Auflage 2018

Die Leitlinie der European Society of Pediatric Infectious Diseases (ESPID) “bone and joint infections” lässt keine Fragen zu dem Thema offen und geht auch auf seltene Konstellationen und Fragestellungen ein: https://journals.lww.com/pidj/Fulltext/2017/08000/Bone_and_Joint_Infections.18.aspx

Eren Gok S, Kaptanoglu E, Celikbas A, et al. Vertebral osteomyelitis: clinical features and diagnosis. Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2014; 20: 1055–60.

Fleege C, Rauschmann M, Arabmotlagh M, Rickert M. Development and current use of local antibiotic carriers in spondylodiscitis: Pilot study on reduction of duration of systemic treatment. Der Orthopäde 2020; 49: 714.

Gariani K, Pham TT, Kressmann B, et al. Three Weeks Versus Six Weeks of Antibiotic Therapy for Diabetic Foot Osteomyelitis: A Prospective, Randomized, Noninferiority Pilot Trial. Clin Infect Dis. 2021;73(7):e1539-e1545. doi:10.1093/cid/ciaa1758

Garner MR, Sethuraman SA, Schade MA, Boateng H. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. J Am Acad Orthop Surg 2020; 28: 309–15.

Garkowski A, Zajkowska A, Czupryna P, Lebkowski W, Letmanowski M, Gołębicki P, Moniuszko A, Ustymowicz A, Pancewicz S, Zajkowska J. Infectious spondylodiscitis - a case series analysis. Adv Med Sci. 2014 Mar;59(1):57-60.

Gomez-Urena EO, Tande AJ, Osmon DR et al: Diagnosis of prosthetic joint infection. Cultures, biomarker ana criteria. Inf Dis Clin N Am 2017; 31: 219-235.

Gouliouris T, Aliyu SH, Brown NM. Spondylodiscitis: update on diagnosis and management. J Antimicrob Chemother. 2010 Nov;65 Suppl 3:iii11-24.

Gould IM, Miró JM, Rybak MJ. Daptomycin: the role of high-dose and combination therapy for Gram-positive infections. Int J Antimicrob Agents. 2013 Sep;42(3):202-10. doi: 10.1016/j.ijantimicag.2013.05.005. Epub 2013 Jul 8. PMID: 23845504.

Glaudemans AWJM, Jutte PC, Cataldo MA, et al. Consensus document for the diagnosis of peripheral bone infection in adults: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement). Eur J Nucl Med Mol Imaging. 2019;46(4):957-970. doi:10.1007/s00259-019-4262-x

Grammatico L, Baron S, Rusch E, et al. Epidemiology of vertebral osteomyelitis (VO) in France: analysis of hospital-discharge data 2002-2003. Epidemiol Infect 2008; 136: 653–60.

Groll AH, Buchheidt D, Heinz W, Bellmann R, Cornely O, Höhl R, et al. S1 Leitlinie Diagnose und Therapie von Candida Infektionen: Gemeinsame Empfehlungen der Deutschsprachigen Mykologischen Gesellschaft (DMykG) und der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG). S1-Leitlinie. AWMF-Registernummer 082 – 005. Stand 07/2020

Grados F, Lescure FX, Senneville E, Flipo RM, Schmit JL, Fardellone P. Suggestions for managing pyogenic (non-tuberculous) discitis in adults. Joint Bone Spine. 2007 Mar;74(2):133-9.

Gustilo RB, Mendoza RM, Williams DN. Problems in the management of type III (severe) open fractures: a new classification of type III open fractures. J Trauma 1984; 24: 742–6.

Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am 1976; 58: 453–8.

Herrera S, Sorli L, Horcajada JP. High-dose daptomycin together with rifampin as salvage therapy for prosthetic joint infections. Med Clin (Barc). 2017;149:223–4.29

Herren C, von der Höh N, Dreimann M. Diagnostik und Therapie der Spondylodiszitis S2k-Leitlinie. AWMF-Registernummer: 151-001Stand: 26.August2020

Herren C, Jung N, Pishnamaz M, Breuninger M, Siewe J, Sobottke R. Spondylodiscitis: Diagnosis and Treatment Options. A Systematic Review. Dtsch Arztebl Int 2017; 114: 875–82

Horrowitz DL et al., Aproach to septic arthritis; American Family Physician; Volume 84, Number 6, September 15, 2011; www.aafp.org/afp/2011/0915/afp20119015p653.pdf; (letzte online Abfrage 07.05.2021)

Izakovicova P, Borens O, Trampuz A: Periprosthetic joint infection: current concepts and outlook. efort Open Rev 2019; 4 482-494. DOI: 10.1302/2058-5241.4.180092.

Jeans E, Holleyman R, Tate D et al: Methicillin sensitive staphylococcus aureus screening and decolonisation in elective hip and knee arthroplasty. J Infect 2018, 77: 405-409.

Jensen AG, Espersen F, Skinhøj P et al. Increasing frequency of vertebral osteomyelitis following Staphylococcus aureus bacteraemia in Denmark 1980-1990. J Infect 1997; 34: 113–8.

Jung N, Seifert H, Siewe J, Fätkenheuer G. Spondylodiszitis [Vertebral osteomyelitis]. Internist (Berl). 2013 Aug;54(8):945-53.

Jung N, Rieg S. Diabetische Fußosteomyelitis. Diabetologe. 2018;14(3):145-152. doi:10.1007/s11428-018-0321-3

Kalkulierte parenterale Initialtherapie bakterieller Erkrankungen bei Erwachsenen – Update 2018 S. 228-238.

Karlsen OE, Borgen P, Bragnes B et al: Rifampicin combination therapy in staphylococcal prothetic joint infections: a randomized controlled trial. J Orthop Surg Res 2020; 15: 365-374.

Kaufmann C., Septic Arthritis/Infection native joints, Infectious disease Advisor, https.//infectiousdiseaseadvisor.com/home/decision-support-in-medicine/infectious-disease/septic-arthritis-native-joints (letzte online Abfrage am 03.03.2021)

Kehrer M, Pedersen C, Jensen TG et al. Increasing incidence of pyogenic spondylodiscitis: a 14-year population-based study. J Infect 2014; 68: 313–20.

Krogsgaard MR, Wagn P, Bengtsson J. Epidemiology of acute vertebral osteomyelitis in Denmark: 137 cases in Denmark 1978-1982, compared to cases reported to the National Patient Register 1991-1993. Acta Orthop Scand. 1998 Oct;69(5):513-7.

Krogstad, P. Hematogenous osteomyelitis in children. In: UpToDate, Post, TW (Ed), UpToDate, Waltham, MA, 2021.

Lazzeri E, Bozzao A, Cataldo MA, et al. Joint EANM/ESNR and ESCMID-endorsed consensus document for the diagnosis of spine infection (spondylodiscitis) in adults. Eur J Nucl Med Mol Imaging 2019; 46: 2464-2487.

Lavery LA, Armstrong DG, Peters EJG, Lipsky BA. Probe-to-bone test for diagnosing diabetic foot osteomyelitis: reliable or relic? Diabetes Care. 2007;30(2):270-274. doi:10.2337/dc06-1572


Lee J. Efficacy of cultures in the management of open fractures. Clin Orthop 1997; : 71–5.


Lestin-Bernstein F, Tietke M, Briedigkeit L, Heese O. Diagnostics and antibiotic therapy for spondylodiscitis. J Med Microbiol. 2018 Jun;67(6):757-768.

Lew DP, Waldvogel FA. Osteomyelitis. Lancet. 2004 Jul 24-30;364(9431):369-79.

Li HK, Rombach I, Zambellas R, Walker AS, McNally MA, Atkins BL, Lipsky BA, Hughes HC, Bose D, Kumin M, et al. Oral versus Intravenous Antibiotics for Bone and Joint Infection. N Engl J Med 2019, 380(5):425-436

Lipsky BA, Berendt AR, Cornia PB, et al. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012;54(12):e132-173. doi:10.1093/cid/cis346

Lipsky BA, Senneville É, Abbas ZG, et al. Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update). Diabetes Metab Res Rev. 2020;36 Suppl 1:e3280. doi:10.1002/dmrr.3280

Lora-Tamayo J, Parra-Ruiz J, Rodriguez-Pardo D, et al. High doses of daptomycin (10 mg/kg/d) plus rifampin for the treatment of staphylococcal prosthetic joint infection managed with implant retention: a comparative study. Diagn Microbiol Infect Dis. 2014;80:66–71.28.

Malizos K, Sarma J, Seaton RA et al.: Daptomycin for the treatment of osteomyelitis and orthopaedic device infections:real-world clinical experience from a European registry. Eur J Clin Microbiol Infect Dis 2016; 35: 111-118.

Mathes CJ, Kingsley G, Field M, Jones A, Weston W C, Phillips M, Walker D, Coakley D, Management of septic arthritis: A Systematic Review, Ann Rheum Dis 2007;66:440–445.

McDonald M, Peel T. Vertebral osteomyelitis and discitis in adults. UptoDate. Literature review current through: Aug 2020.

Merritt K. Factors increasing the risk of infection in patients with open fractures. J Trauma 1988; 28: 823–7.Morawietz L, Gehrke T, Claßen R-A et al: Vorschlag für eine Konsensus-Klassifikation der periprothetischen Membran gelockerter Hüft-und Knieendoprothesen. Pathologe 2004; 25: 375-384.

MiQ: Qualitätsstandards in der mikrobiologisch-infektiologischen Diagnostik - 9783437415708 | Elsevier GmbH. Accessed January 8, 2022. https://shop.elsevier.de/miq-qualitaetsstandards-in-der-mikrobiologisch-infektiologischen-diagnostik-9783437415708.html

Murillo O, Roset A, Sobrino B, Lora-Tamayo J, Verdaguer R, Jiménez-Mejias E, Nolla JM, Colmenero Jde D, Ariza J. Streptococcal vertebral osteomyelitis: multiple faces of the same disease. Clin Microbiol Infect. 2014 Jan;20(1):O33-8.

Mylona E, Samarkos M, Kakalou E, Fanourgiakis P, Skoutelis A. Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics. Semin Arthritis Rheum. 2009 Aug;39(1):10-7.

Ndosi M, Wright-Hughes A, Brown S, et al. Prognosis of the infected diabetic foot ulcer: a 12-month prospective observational study. Diabet Med. 2018;35(1):78-88. doi:10.1111/dme.13537

Nolla JM, Ariza J, Gomez-Vaquero C, Fiter J: Spontaneous pyogenic vertebral osteomyelitis in nondrug-users. Semin Arthritis Rheum 2002, 31:271-278.

Nonvertebral osteomyelitis in adults: Clinical manifestations and diagnosis - UpToDate. Accessed January 8, 2022. https://www.uptodate.com/contents/nonvertebral-osteomyelitis-in-adults-clinical-manifestations-and-diagnosis

Nonvertebral osteomyelitis in adults: Treatment - UpToDate. Accessed January 8, 2022. https://www.uptodate.com/contents/nonvertebral-osteomyelitis-in-adults-treatment

Ochsner P, Zimmerli W, Nötzli H: Die periprothetische infektion. In: Ochsner P, Borens O, Bodler P-M et al: Infektionen des Bewegungsapparates. Grundlagen, Prophylaxe, Diagnostik und Therapie. Überarb. Nachdruck der 2. Aufl. Wehrheim 2016. S. 94-113.

Oral versus Intravenous Antibiotics for Bone and Joint Infection | NEJM. Accessed January 8, 2022. https://www.nejm.org/doi/full/10.1056/NEJMoa1710926

Otto-Lambertz C, Yagdiran A,Wallscheid F, Eysel P, Jung N: Periprosthetic infection in joint replacement—diagnosis and treatment. Dtsch Arztebl Int 2017; 114: 347–53. DOI: 10.3238/arztebl.2017.0347

Osmon DR, Berbari EF, Berendt AR et al: Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. CID 2013:56, e1-e25.

Park KH, Cho OH, Lee JH, Park JS, Ryu KN, Park SY, Lee YM, Chong YP, Kim SH, Lee SO, et al. Optimal Duration of Antibiotic Therapy in Patients With Hematogenous Vertebral Osteomyelitis at Low Risk and High Risk of Recurrence. Clin Infect Dis 2016, 62(10):1262-1269

Patzakis MJ, Bains RS, Lee J, et al. Prospective, randomized, double-blind study comparing single-agent antibiotic therapy, ciprofloxacin, to combination antibiotic therapy in open fracture wounds. J Orthop Trauma 2000; 14: 529–33.Podbielski A, Abele-Horn M, BückerA, et al: Mikrobiologische Diagnostik der Arthritis und Osteomyelitis (MIQ 18/2014) IN: Podbielski A, Abele-Horn M, Herrmann M, Kniehl E, Mauch H, Rüssmann H (eds.). Mikrobiologisch-infektologische Qualitätsstandards.Urban & Fischer 2014

Reith G, Wyen H, Wafaisade A, et al. Realität initialer Versorgung offener Frakturen in deutschen Notaufnahmen. Unfallchirurg 2016; 119: 642–7.

Renz N, Trampuz A: Periprothetische Infektionen: aktueller Stand der Diagnostik und Therapie. Orthopädie & Rheuma 2015; 18 (6): 20-28.Riechelmann F, Kaiser P, Arora R. Primäres Weichteilmanagement bei offenen Frakturen. Oper Orthop Traumatol 2018; 30: 294–308.

Rieg S, Ernst A, Peyerl-Hoffmann G, Joost I, Camp J, Hellmich M, Kern WV, Kaasch AJ, Seifert H. Combination therapy with rifampicin or fosfomycin in patients with Staphylococcus aureus bloodstream infection at high risk for complications or relapse: results of a large prospective observational cohort. J Antimicrob Chemother. 2020 Aug 1;75(8):2282-2290.

Robineau O, Nguyen S, Senneville E. Optimising the quality and outcomes of treatments for diabetic foot infections. Expert Rev Anti Infect Ther. 2016;14(9):817-827. doi:10.1080/14787210.2016.1214072

Roblot F, Besnier JM, Juhel L, Vidal C, Ragot S, Bastides F, Le Moal G, Godet C, Mulleman D, Azaïs I, Becq-Giraudon B, Choutet P. Optimal duration of antibiotic therapy in vertebral osteomyelitis. Semin Arthritis Rheum. 2007 Apr;36(5):269-77.

Ryang, Y., Akbar, M. Die eitrige Spondylodiszitis: Symptome, Diagnostik und Behandlungsstrategien. Orthopäde 2020; 49: 691–701.

Schaberg T, Bauer T, Brinkmann F, Diel R, Feiterna-Sperling C, Haas W, et al. Tuberkulose im Erwachsenenalter. S2k-Leitlinie. AWMF-Registernummer 020 – 019. Stand 06/2017

Schmitt SK. Osteomyelitis. Infect Dis Clin North Am. 2017;31(2):325-338. doi:10.1016/j.idc.2017.01.010

Sconfienza LM, Signore A, Cassar-Pullicino V, et al. Diagnosis of peripheral bone and prosthetic joint infections: overview on the consensus documents by the EANM, EBJIS, and ESR (with ESCMID endorsement). Eur Radiol. 2019;29(12):6425-6438. doi:10.1007/s00330-019-06326-1

Seaton RA, Menichetti F, Dalekos G, Beiras-Fernandez A, Nacinovich F, Pathan R, Hamed K. Evaluation of Effectiveness and Safety of High-Dose Daptomycin: Results from Patients Included in the European Cubicin(®) Outcomes Registry and Experience. Adv Ther. 2015 Dec;32(12):1192-205. doi: 10.1007/s12325-015-0267-4. Epub 2015 Nov 26. PMID: 26610384; PMCID: PMC4679787.

Seaton RA, Gonzalez-Ruiz A, Cleveland KO et al.: Realworld daptomycin use across wide geographical regions: results from a pooled analysis of CORE and EU-CORE. Ann Clin Microbiol Antimicrob 2016; 15: 18.

Selva Olid A, Solà I, Barajas-Nava LA, Gianneo OD, Bonfill Cosp X, Lipsky BA. Systemic antibiotics for treating diabetic foot infections. Cochrane Database Syst Rev. 2015;(9):CD009061. doi:10.1002/14651858.CD009061.pub2

Senneville E, Caillon J, Calvet B, Jehl F: Towards a definition of daptomycin optimal dose: Lessons learned from experimental and clinical data. Int J Antimicrob Agents 2016; 47: 12-19.

Senneville E, Joulie D, Blondiaux N, Robineau O. Surgical techniques for Bone Biopsy in Diabetic Foot Infection, and association between results and treatment duration. J Bone Jt Infect. 2020;5(4):198-204. doi:10.7150/jbji.45338

Sobottke R, Seifert H, Fätkenheuer G, Schmidt M, Gossmann A, Eysel P. Current diagnosis and treatment of spondylodiscitis. Dtsch Arztebl Int. 2008 Mar;105(10):181-7.

Spellberg B, Lipsky BA. Systemic antibiotic therapy for chronic osteomyelitis in adults. Clin Infect Dis. 2012;54(3):393-407. doi:10.1093/cid/cir842

S2k Leitlinie: Kalkulierte parenterale Initialtherapie bakterieller Erkrankungen bei Erwachsenen. AWMF-Registernummer 082-006.

Spilf. Spondylodiscites infectieuses primitives, et secondaires à un geste intradiscal, sans mise en place de matériel. Recommandations [Primary infectious spondylitis, and following intradiscal procedure, without prothesis. Recommendations]. Med Mal Infect. 2007 Sep;37(9):573-83.

Sporer SM, Rogers T, Abella L: Methicillin-Resistant and Methicillin-Sensitive Staphylococcus aureus Screening and Decolonisation to Reduce Surgical Site Infection in Elective Total Joint Arthroplasty. J Arthroplasty 2016, 31: 144-147.Stammschulte T, Isner C, Kern WV. Daptomycin (Cubicin®) – aktuelle Diskussion der Einsatzgebiete und Dosierung. Arzneiverordnung in der Praxis Band 44 Heft 2 April 2017

Suerbaum S, Burchard GD, Kaufmann SHE, Schulz TF. Medizinische Mikrobiologie und Infektiologie. Springer-Verlag Berlin Heidelberg 2020, 9. Auflage, ISBN 978-3-662-61384-9

Sur A, Tsang K, Brown M, Tzerakis N. Management of adult spontaneous spondylodiscitis and its rising incidence. Ann R Coll Surg Engl. 2015 Sep;97(6):451-5.

Surveillance ATLAS of Infectious diseases: MRSA-Anteil https://www.ecdc.europa.eu/en/surveillance-and-disease-data

Tande AJ, Patel R: Prosthetic joint infection. Clin Micobiol Rev 2014; 27: 302-345.

Tande AJ, Gomez-Urena EO, Berbari EF et al: Management of prosthetic joint infection. Infect Dis Clin N AM 2017; 31: 237-252,

Taylor DG, Buchholz AL, Sure DR, Buell TJ, Nguyen JH, Chen CJ, Diamond JM, Washburn PA, Harrop J, Shaffrey CI, Smith JS. Presentation and Outcomes After Medical and Surgical Treatment Versus Medical Treatment Alone of Spontaneous Infectious Spondylodiscitis: A Systematic Literature Review and Meta-Analysis. Global Spine J. 2018 Dec;8(4 Suppl):49S-58S.

Thabit AK, Fatani DF, Bamakhrama MS, Barnawi OA, Basudan LO, Alhejaili SF. Antibiotic penetration into bone and joints: An updated review. Int J Infect Dis. 2019 Apr;81:128-136. doi: 10.1016/j.ijid.2019.02.005. Epub 2019 Feb 14. PMID: 30772469.

Tiemann A et al: S2k-Leitlinie Akute und chronische exogene Osteomyelitis langer Röhrenknochen des Erwachsenen 2017. AwMF Register 012/033. Stand 12/2017.Tone A, Nguyen S, Devemy F, et al. Six-week versus twelve-week antibiotic therapy for nonsurgically treated diabetic foot osteomyelitis: a multicenter open-label controlled randomized study. Diabetes Care. 2015;38(2):302-307. doi:10.2337/dc14-1514
Vossen MG, Gattringer R, Thalhammer F, Militz M, Hischebeth G: 10. Knochen- und Gelenkinfektionen. In: Bodmann K-F, Grabein B, Kresken M et al. Kalkulierte parenterale Initialtherapie bakterieller Erkrankungen bei Erwachsenen - Update 2018. PEG S2k Leitlinie. AwMF-Registernummer 082-006. Stand 25.07.2019. S.228-238.

Vossen MG et al.: Knochen- und Gelenkinfektionen. In: Bodmann et al: S2k Leitlinie
Walter G, Kemmerer M, Kappler C, Hoffmann R: Treatment algorithms for chronic osteomyelitis. Dtsch Arztebl Int 2012; 109(14): 257–64. DOI: 10.3238/arztebl.2012.0257

Yagdiran A, Otto-Lambertz C, Lingscheid KM, Sircar K, Samel C, Scheyerer MJ, Zarghooni K, Eysel P, Sobottke R, Jung N, Siewe J. Quality of life and mortality after surgical treatment for vertebral osteomyelitis (VO): a prospective study. Eur Spine J. 2020 Jul 1. doi: 10.1007/s00586-020-06519-z.

Zimmerli W. Clinical practice. Vertebral osteomyelitis. N Engl J Med. 2010 Mar 18;362(11):1022-9.